Homocysteine, Total

Total Homocysteine measures the level of homocysteine in the blood, an amino acid involved in methionine metabolism. Elevated homocysteine levels may be associated with cardiovascular risk and certain vitamin deficiencies.

Homocysteine levels are influenced by vitamin B12, B6, and folate status.

Homocysteine testing helps assess:

• Cardiovascular risk factors
• Vitamin B12 deficiency
• Folate deficiency
• Vitamin B6 status
• Methylation function

Reference Range (General Guidance):

Typically 5–15 µmol/L
Optimal levels are often considered toward the lower end of the reference range.

What Your Results May Mean

• Elevated Homocysteine: May be associated with increased cardiovascular risk, vitamin deficiencies, or impaired methylation.
• Low or Normal Homocysteine: Generally consistent with adequate vitamin status and normal metabolism.

Results are often interpreted alongside Vitamin B12, Folate, and other cardiovascular markers for a more complete assessment.